| Home | Win % | Away | Win % |
| Chicago White Sox | 33 | Atlanta Braves | 67 |
| Chicago Cubs | 65 | Colorado Rockies | 35 |
| Washington Nationals | 53 | Pittsburgh Pirates | 47 |
| Baltimore Orioles | 60 | Kansas City Royals | 40 |
| Miami Marlins | 53 | Los Angeles Angels | 47 |
| Philadelphia Phillies | 60 | Cincinnati Reds | 40 |
| Tampa Bay Rays | 53 | Texas Rangers | 47 |
| New York Mets | 56 | Detroit Tigers | 44 |
| Houston Astros | 52 | Toronto Blue Jays | 48 |
| Oakland Athletics | 47 | Boston Red Sox | 53 |
| Seattle Mariners | 54 | Cleveland Guardians | 46 |
| Arizona Diamondbacks | 50 | New York Yankees | 50 |
| San Diego Padres | 52 | St. Louis Cardinals | 48 |
| Los Angeles Dodgers | 62 | San Francisco Giants | 38 |
| Home | Win % | Away | Win % |
| Baltimore Orioles | 61 | Los Angeles Angels | 39 |
| Philadelphia Phillies | 47 | Atlanta Braves | 53 |
| New York Mets | 52 | Milwaukee Brewers | 48 |
| Miami Marlins | 59 | Pittsburgh Pirates | 41 |
| Tampa Bay Rays | 50 | Toronto Blue Jays | 50 |
| Cincinnati Reds | 60 | Washington Nationals | 40 |
| Chicago White Sox | 44 | Detroit Tigers | 56 |
| Kansas City Royals | 42 | Minnesota Twins | 58 |
| Houston Astros | 53 | New York Yankees | 47 |
| Texas Rangers | 55 | Chicago Cubs | 45 |
| Oakland Athletics | 51 | Cleveland Guardians | 49 |
| Seattle Mariners | 58 | Boston Red Sox | 42 |
| Arizona Diamondbacks | 61 | Colorado Rockies | 39 |
| San Diego Padres | 60 | San Francisco Giants | 40 |
| Los Angeles Dodgers | 59 | St. Louis Cardinals | 41 |
| Home | Win % | Away | Win % |
| New York Mets | 50 | Milwaukee Brewers | 50 |
| Chicago White Sox | 45 | Detroit Tigers | 55 |
| Baltimore Orioles | 59 | Los Angeles Angels | 41 |
| Philadelphia Phillies | 46 | Atlanta Braves | 54 |
| Oakland Athletics | 44 | Cleveland Guardians | 56 |
| Kansas City Royals | 43 | Minnesota Twins | 57 |
| Miami Marlins | 56 | Pittsburgh Pirates | 44 |
| Tampa Bay Rays | 53 | Toronto Blue Jays | 47 |
| Cincinnati Reds | 62 | Washington Nationals | 38 |
| Texas Rangers | 54 | Chicago Cubs | 46 |
| Houston Astros | 53 | New York Yankees | 47 |
| San Diego Padres | 55 | San Francisco Giants | 45 |
| Arizona Diamondbacks | 66 | Colorado Rockies | 34 |
| Los Angeles Dodgers | 64 | St. Louis Cardinals | 36 |
| Seattle Mariners | 60 | Boston Red Sox | 40 |
| Home | Win % | Away | Win % |
| New York Mets | 51 | Milwaukee Brewers | 49 |
| Philadelphia Phillies | 48 | Atlanta Braves | 52 |
| Tampa Bay Rays | 54 | Toronto Blue Jays | 46 |
| Miami Marlins | 59 | Pittsburgh Pirates | 41 |
| Houston Astros | 56 | New York Yankees | 44 |
| Seattle Mariners | 59 | Boston Red Sox | 41 |
| Oakland Athletics | 44 | Cleveland Guardians | 56 |
| Arizona Diamondbacks | 66 | Colorado Rockies | 34 |
| San Diego Padres | 59 | San Francisco Giants | 41 |
| Los Angeles Dodgers | 64 | St. Louis Cardinals | 36 |
| Home | Win % | Away | Win % |
| Baltimore Orioles | 63 | Los Angeles Angels | 37 |
| Chicago White Sox | 42 | Detroit Tigers | 58 |
| Kansas City Royals | 44 | Minnesota Twins | 56 |
| Houston Astros | 60 | New York Yankees | 40 |
| Miami Marlins | 56 | Pittsburgh Pirates | 44 |
| San Diego Padres | 54 | San Francisco Giants | 46 |
| Los Angeles Dodgers | 67 | St. Louis Cardinals | 33 |
| Tampa Bay Rays | 56 | Toronto Blue Jays | 44 |
| Cincinnati Reds | 56 | Washington Nationals | 44 |
| Texas Rangers | 53 | Chicago Cubs | 47 |
| Oakland Athletics | 42 | Cleveland Guardians | 58 |
| Seattle Mariners | 61 | Boston Red Sox | 39 |
| Arizona Diamondbacks | 70 | Colorado Rockies | 30 |
| Home | | Draw | | Away |
| New England Revolution | 42 | 27 | 31 | Chicago Fire |
| New York Red Bulls | 41 | 28 | 31 | Inter Miami |
| Charlotte | 29 | 35 | 37 | Columbus Crew |
| FC Cincinnati | 49 | 28 | 24 | New York City |
| Orlando City | 44 | 34 | 23 | Austin FC |
| Toronto FC | 37 | 29 | 35 | Atlanta Utd |
| Vancouver Whitecaps | 46 | 29 | 25 | Real Salt Lake |
| Sporting Kansas City | 43 | 35 | 22 | Los Angeles Galaxy |
| St. Louis City | 43 | 31 | 26 | DC United |
| Colorado Rapids | 36 | 36 | 28 | Houston Dynamo |
| Los Angeles FC | 42 | 33 | 26 | Nashville SC |
| Portland Timbers | 42 | 31 | 27 | Philadelphia Union |
| San Jose Earthquakes | 32 | 38 | 30 | Seattle Sounders |
